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A high‐resolution comparative radiation hybrid map of equine chromosome 4q12–q22
Author(s) -
Dierks C.,
Mömke S.,
Drögemüller C.,
Leeb T.,
Chowdhary B. P.,
Distl O.
Publication year - 2006
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2006.01510.x
Subject(s) - biology , synteny , radiation hybrid mapping , sequence tagged site , genetics , breakpoint , chromosome , chromosome regions , gene , gene mapping , gene map , candidate gene , computational biology
Summary In this study, we present a comprehensive 5000‐rad radiation hybrid map of a 40‐cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene‐associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12–q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12–q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human–equine comparative map, which allows the identification of candidate genes underlying traits of interest.