Premium
Comparison of genetic models for analysing the effects of a Pvu II polymorphism in the oestrogen receptor 1 ( ESR1 ) gene on prolificacy in an Iberian × Meishan pig population
Author(s) -
Braglia S.,
Ramírez O.,
Noguera J. L.,
Tomás A.,
Ovilo C.,
Varona L.
Publication year - 2006
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2006.01500.x
Subject(s) - biology , linkage disequilibrium , genetics , disequilibrium , allele , population , mutation , gene , haplotype , demography , medicine , sociology , ophthalmology
Summary The effect of a previously reported Pvu II polymorphism in oestrogen receptor 1 ( ESR1 ) was analysed in an F 2 population of Iberian × Meishan pigs. We tested three hypotheses: (1) that a causal mutation was fixed in the parental populations, (2) that a causal mutation existed that was in complete linkage disequilibrium with the alleles of the Pvu II polymorphism and (3) that a causal mutation existed in linkage disequilibrium within each parental population. The third model was the most plausible based on the available data. ESR1 alleles displayed different patterns of linkage disequilibrium with the causal mutation in each of the parental populations and the Pvu II polymorphism was clearly not the causal mutation. As a consequence, the use of the ESR1 mutation for selection must be evaluated for a particular pig population before it is applied.