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Refinement of quantitative trait loci on bovine chromosome 18 affecting health and reproduction in US Holsteins
Author(s) -
Muncie S. A.,
Cassady J. P.,
Ashwell M. S.
Publication year - 2006
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2006.01425.x
Subject(s) - quantitative trait locus , biology , sire , genetics , family based qtl mapping , locus (genetics) , candidate gene , selection (genetic algorithm) , trait , chromosome , gene , gene mapping , zoology , artificial intelligence , computer science , programming language
Summary Selection for increased milk yield is associated with decreased fertility in US Holsteins. Previously, a putative quantitative trait locus (QTL) on chromosome 18 affecting daughter pregnancy rate (DPR) was identified in one family. Our aim was to determine the validity of the QTL using additional markers and an extended pedigree. Twelve markers were genotyped in 940 descendants of the original sire in which the QTL was identified. Analysis of the extended pedigree detected significant and suggestive QTL for DPR, productive life and somatic cell score. Further analysis is underway to refine the QTL region so that positional candidate genes can be identified.