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Cytogenetic mapping of immunity‐related genes in the domestic horse
Author(s) -
Musilova P.,
Kubickova S.,
VychodilovaKrenkova L.,
Kralik P.,
Matiasovic J.,
Hubertova D.,
Rubes J.,
Horin P.
Publication year - 2005
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2005.01348.x
Subject(s) - biology , synteny , genetics , gene , candidate gene , microsatellite , gene mapping , fluorescence in situ hybridization , genome , allele , chromosome
Summary Chromosomal locations of 19 horse immunity‐related loci ( CASP1, CD14, EIF5A, FCER1A, IFNG, IL12A, IL12B, IL12RB2, IL1A, IL23A, IL4, IL6, MMP7, MS4A2, MYD88, NOS2A, PTGS2, TFRC and TLR2 ) were determined by fluorescence in situ hybridization. For IFNG and PTGS2 , this study is a confirmation of their previously reported position. In addition, microsatellite ( HMBr1 ) was localized in the same region as IFNG. All genes were assigned to regions of conserved synteny and the data obtained in this study enhance the comparative human–horse map. Cytogenetic localization of IL6 to ECA4q14–q21.1 suggested a new breakage point that changes the order of loci compared with HSA7. The map assignments of these loci serve as anchors for other loci and will aid in the search for candidate genes associated with traits in the horse.