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Assignment of the casein kinase II gene family to cattle chromosomes
Author(s) -
Gao Q,
Li L,
Womack J E
Publication year - 1997
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1997.00092.x
Subject(s) - biology , genetics , gene , casein kinase 2 , cyclin dependent kinase 2 , cell cycle
Theileriosis, or East Coast fever, a parasitic disease in cattle, is associated with overexpression of casein kinase II. Casein kinase II is composed of two catalytic subunits (α or α') and two regulatory β subunits. The genes encoding these subunits of casein kinase II were mapped to bovine chromosomes by polymerase chain reaction analysis of a well‐characterized bovine × rodent somatic hybrid cell panel. The α‐subunit (CSNK2A1) was mapped to bovine chromosome 13, the α'‐subunit (CSNK2A2) to chromosome 5 and the β‐subunit (CSNK2B) to chromosome 23. Both CSNK2A1 and CSNK2B mapped to known regions of conserved synteny between human and cattle, while CSNK2A2 defined a new homology segment between the human and bovine genomes.