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The porcine TTR locus maps to chromosome 6q
Author(s) -
Archibald A L,
Couperwhite S,
Jiang Z H
Publication year - 1996
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1996.tb00977.x
Subject(s) - biology , genetics , locus (genetics) , restriction fragment length polymorphism , single strand conformation polymorphism , coding region , transthyretin , complementary dna , microbiology and biotechnology , gene , genotype , exon , endocrinology
Summary The sequence of a cDNA clone encoding porcine transthyretin (prealbumin) was used to develop polymorphic markers for the TTR locus. The single‐strand conformation polymorphism (SSCP) detected is caused by a silent AIT mutation in the penultimate coding codon and can also be revealed as a SacI restriction fragment length polymorphism (RFLP). The TTR locus was mapped to chromosome 6q by segregation and linkage analysis with these polymorphisms. This assignment confirms the predictions of homology between human chromosome 18 and pig chromosome 6q2.5‐2.6.