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The porcine skeletal muscle ryanodine receptor gene structure coding region 1 to 10 614 harbouring 71 exons
Author(s) -
Wen G,
Leeb T,
Reinhart B,
Brenig B
Publication year - 1996
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1996.tb00973.x
Subject(s) - ryr1 , ryanodine receptor , biology , exon , gene , genetics , skeletal muscle , microbiology and biotechnology , genomic dna , genomic organization , coding region , genome , receptor , anatomy
Summary The skeletal muscle ryanodine receptor (RYR1) belongs to a family of calcium release channels that are expressed in different tissues. The RYR1 gene is one of the largest genes characterized, so far, containing a 15 253 nucleotide ORF in swine. To study the genomic organization of the porcine skeletal muscle ryanodine receptor gene we have isolated seven genomic fragments spanning 72.7 kb of chromosomal DNA of chromosome 6q12. This region harbours exons 1 to 71 coding for 3538 amino acids (69.6%) of the ryanodine receptor 1.