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Genetic polymorphism of the sixth component of complement (C6) in dogs
Author(s) -
Shibata T,
Abe T,
Tanabe Y
Publication year - 1995
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1995.tb02641.x
Subject(s) - biology , locus (genetics) , genetics , allele , breed , phenotype , gene , isoelectric focusing , biochemistry , enzyme
Summary Using agarose gel isoelectric focusing and immunoblotting with rabbit anti‐rabbit C6, a genetic polymorphism was found in the sixth component of complement (C6) in 18 Asian native breeds or populations and three European breeds of dog. The C6 locus was highly polymorphic. The phenotype distribution data indicated that dog C6 phenotypes were controlled by seven codominant alleles, C6 A , C6 B , C6 C , C6 D , C6 E , C6 F and C6 G , at a single autosomal locus. Breed differences were observed among the gene frequencies, especially between Asian and European breeds. Two gene flows from the adjacent areas into Japanese native dogs were postulated.