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Association between the bovine major histocompatibility complex and chronic posterior spinal paresis – a form of ankylosing spondylitis – in Holstein bulls
Author(s) -
Park C A,
Hines H C,
Monke D R,
Threlfall W L
Publication year - 1993
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1993.tb00919.x
Subject(s) - ankylosing spondylitis , allele , biology , offspring , major histocompatibility complex , spondylitis , human leukocyte antigen , haplotype , genetic association , population , genetics , immunology , medicine , antigen , genotype , gene , single nucleotide polymorphism , pregnancy , environmental health
Summary A highly significant association was found between the bovine MHC class I antigen BoLA‐A8 and a form of vertebral osteophytosis/ankylosing spondylitis known as chronic posterior spinal paresis (PSP) in Holstein bulls ( P < 0.001). In a population study, restricted to unrelated bulls, BOLA‐A8 was significantly associated with PSP ( P = 0.0015) with a relative risk of 34.6. In a family study, one PSP bull, BoLA A8/A20, sired 13 offspring. BOLA‐A8 was significantly associated with PSP ( P = 0–0008). All five PSP sons inherited the A8 allele and the eight healthy sons each inherited the A20 allele. In three other families a complete association of BOLA‐A8 and PSP was observed. Lod score analysis, using all available families, indicated a significant linkage between BoLA and PSP (lod score = 6–9). Based on clinical observation, pathology, age/sex predilection, and a strong association with a class I MHC molecule, this inflammatory disease appears analogous to the human condition known as ankylosing spondylitis.