Premium
Influence of different B ‐complex recombinants on the outcome of Rous sarcomas in chickens
Author(s) -
Aeed P. A.,
Collins W. M.,
Briles W. E.,
Zsigray R. M.
Publication year - 1993
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1993.tb00283.x
Subject(s) - biology , rous sarcoma virus , haplotype , virology , genotype , genetics , immunology , virus , gene
Summary Seven major histocompatibility ( B ) complex recombinants were evaluated for anti‐Rous sarcoma response. In experiment 1, the B R5 (F21‐G19) recombinant haplotype both homozygous and in heterozygous combinations with B 19 and B 21 haplotypes were compared to B 19 / B 19 and B 21 / B 21 chickens to determine the relative influence of the B F versus B G chromosomal segments on regression of Rous sarcoma virus‐induced tumours. In experiment 2, six recombinant haplotypes B R1 (F24‐G23), B R2 (F2‐G23), B R3 (F2‐G23), B R4 (F2‐G23), B R6 (F21‐G23) and B R8 (F2‐G2a,23) present in chickens heterozygous for normal haplotypes B 19 , B 23 or B 26 were compared for anti‐sarcoma response. A total of 1328 chickens were blood typed for B alloanti‐gens at 17 days of age, inoculated in the wingweb with Rous sarcoma virus at 6 weeks and monitored for anti‐tumour immune response over a 10‐week period. Genotypes which shared the same B F haplotype, but differed in their B G regions, had similar anti‐tumour responses, implicating the B F but not the B G region in tumour regression. Chickens carrying B F2 or B F21 had a strong anti‐tumour response, while B F24 conferred a weaker response, regardless of the accompanying normal haplotype.