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Genetic polymorphism of the sixth component of complement (C6) in the pig
Author(s) -
Shibata T.,
Abe T.,
Akita T.
Publication year - 1993
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1993.tb00247.x
Subject(s) - biology , locus (genetics) , genetics , allele , breed , isoelectric focusing , gene , enzyme , biochemistry
Summary Using agarose gel isoelectric focusing and immunoblotting with rabbit anti‐rabbit C6, a genetic polymorphism has been found in the sixth component of complement (C6) in six breeds of pigs. The C6 locus was highly polymorphic. Family data indicated that pig C6 pheno‐types were inherited by means of five codomonant alleles named C6 A , C6 B , C6 C , C6 D and C6 E at a single autosomal locus. C6 deficiency in two of 241 individuals tested was found, which suggested the presence of a null allele in pig populations. Marked breed differences among the gene frequencies and heterozygosities at C6 locus were observed.