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Assignment of the porcine tumour necrosis factor alpha and beta genes to the chromosome region 7p11‐q11 by in situ hybridization
Author(s) -
SOLINAS S.,
PAULI U.,
KUHNERT P.,
PETERHANS E.,
FRIES R.
Publication year - 1992
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1992.tb00140.x
Subject(s) - biology , locus (genetics) , in situ hybridization , major histocompatibility complex , gene , tumor necrosis factor alpha , histocompatibility , comparative genomic hybridization , chromosome , genetics , gene mapping , microbiology and biotechnology , in situ , beta (programming language) , gene expression , human leukocyte antigen , immunology , antigen , chemistry , organic chemistry , computer science , programming language
Summary. The loci of the porcine tumour necrosis factor genes, alpha (TNFA) and beta (TNFB), have been chromosomally assigned by radioactive in situ hybridization. The genomic probes for TNFA and TNFB yielded signals above 7p11‐q111, a region that has been shown earlier to carry the porcine major histocompatibility locus (SLA). These mapping data along with preliminary molecular studies suggest a genomic organization of the SLA that is similar to that of human and murine major histocompatibility complexes.