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Localization of the ß‐subunit of follicle stimulating hormone in cattle and sheep by in situ hybridization
Author(s) -
HEDIGER R.,
JOHNSON S. E.,
HETZEL D. J. S.
Publication year - 1991
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1991.tb00673.x
Subject(s) - biology , synteny , locus (genetics) , homologous chromosome , gene mapping , gene , complementary dna , genetics , chromosome , microbiology and biotechnology , in situ hybridization , gene expression
Summary. The locus for the ß‐subunit of the follicle stimulating hormone gene (FSHB) has been determined in both cattle and sheep by in situ hybridization of a bovine and an ovine cDNA probe, respectively, to metaphase chromosomes. Our results show that the FSHB locus is on cattle chromosome 15 in the region of bands q24‐qter and in sheep on the cytogenetically homologous chromosome 15, also in the region q24‐qter. The mapping of the FSHB gene in cattle together with the location of other genes (CAT, HBB and PTH) previously found to be syntenic in cattle and on human chromosome 11p, defines an evolutionarily conserved synteny. The localization of the FSHB gene to a cytogenetically homologous region in cattle and sheep is consistent with the hypothesis of extesively conserved chromosome structure in these two species.