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A bovine class I major histocompatibility complex molecule plus a Theileria parva antigen resembles mouse H‐2K d
Author(s) -
GODDEERIS B. M.
Publication year - 1990
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1990.tb03243.x
Subject(s) - biology , theileria parva , major histocompatibility complex , cytotoxic t cell , clone (java method) , ctl* , virology , antigen , microbiology and biotechnology , monoclonal antibody , epitope , mhc restriction , mhc class i , cd8 , antibody , parasite hosting , genetics , gene , in vitro , world wide web , computer science
Summary Two BoT2 + , BoT8 + cytotoxic T cell clones were generated from peripheral blood of a steer immunized with the intracellular protozoan parasite Theileria parva . Both cytotoxic T cell clones appeared to be restricted by the same major histocompatibility complex (MHC) molecule and were specific for the immunizing parasite clone. However, one of the two clones also recognized uninfected mouse cell lines carrying the H‐2 d haplotype. Inhibition of cytotoxicity with monoclonal antibodies specific for polymorphic determinants on H‐2 molecules confirmed that this CTL clone recognized the H‐2K d MHC molecule. These results extend to the bovine system observations in other species that foreign MHC mimics self MHC plus antigen.