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Genetic polymorphism of complement factor H in cattle
Author(s) -
TABEL H.,
GROAT H. J.,
KRAAY G. J.,
ASTON W. P.
Publication year - 1990
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1990.tb03216.x
Subject(s) - biology , allele , mendelian inheritance , genetics , locus (genetics) , polymorphism (computer science) , phenotype , population , polyacrylamide gel electrophoresis , genetic marker , microbiology and biotechnology , gene , biochemistry , enzyme , demography , sociology
Summary Bovine factor H was found to be polymorphic by the combined techniques of SDS‐polyacrylamide electrophoresis of bovine plasma and immunoblotting. Three phenotypes (S, SF, F) were identified in a sample population of 149 cattle. Variant S and F differed by an apparent molecular weight of 5000 daltons. Family studies demonstrated Mendelian segregation of variants S and F. The data indicate that these genetic variants of bovine factor H are encoded by two codominant alleles at a single autosomal locus.