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Monoclonal antibody differentiates chicken A system alloantigens *
Author(s) -
FULTON J. E.,
BRILES R. W.,
LAMONT S. J.
Publication year - 1990
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1990.tb03205.x
Subject(s) - monoclonal antibody , biology , antigen , hemagglutination , serology , antibody , monoclonal , allele , microbiology and biotechnology , virology , locus (genetics) , immunology , genetics , gene
Summary A monoclonal antibody (ISU‐cA) was produced that recognized certain alloantigens of the chicken A blood group locus. Antigens produced by alleles A 3 , A 4 and A 8 were positive, and those produced by A 2 and A 5 were negative, by haemagglutination. The specificity of ISU‐cA for chicken A blood group antigens was demonstrated by serologic analyses, genetic crosses and competitive inhibition of binding by anti‐A alloantisera. To our knowledge, this is the first reported monoclonal antibody against a chicken blood group alloantigen system other than the B complex.