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The swine leucocyte antigen (SLA) complex and Sinclair swine cutaneous malignant melanoma
Author(s) -
TISSOT R. G.,
BEATTIE C. W.,
JR M. S. AMOSS
Publication year - 1989
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1989.tb00841.x
Subject(s) - haplotype , biology , allele , locus (genetics) , melanoma , weaning , herd , in utero , antigen , immunology , genetics , gene , pregnancy , endocrinology , fetus , zoology
Summary. Cutaneous malignant melanoma of Sinclair swine (SSCM) is an inherited neoplasm present at birth in a majority of affected animals. We have characterized the swine leucocyte antigen (SLA) complex of the Sinclair herd at Texas A & M University using a one‐way mixed lymphocyte test and found that one particular haplotype, arbitrarily identified as haplotype B , is associated with the expression of SSCM. Only a single dose of the B haplotype is required for a dominant allele at a ‘tumour initiator’ locus to be fully penetrant. In addition, swine homozygous for haplotype B develop more primary tumours between birth and weaning than those heterozygous for the B haplotype. Taken together, these findings indicate that tumour initiation, in utero , and expression between birth and weaning may involve different mechanisms.