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Serological and genetic study of the ELA W21 specificity
Author(s) -
HIRNI H.,
LAZARY S.,
GERBER H.
Publication year - 1988
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1988.tb00830.x
Subject(s) - locus (genetics) , biology , allele , gene , genetics , antigen , major histocompatibility complex , gene product , microbiology and biotechnology , gene expression
Summary. Investigations on the W21 specificity showed that this antigen is expressed on lymphocytes and platelets but not on erythrocytes. The molecule carrying the antigen W21 moves in the cell membrane independently from ELA locus A and B encoded antigens, as observed in ‘lysostripping’. The W21 specificity occurs with very different gene frequencies in various breeds. In informative families it segregates together with defined gene products of the MHC region. The data suggest strongly that the W21 specificity belongs to the ELA system as a class I gene product, but is governed by a separate locus than the known locus A and locus B allelic series.