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Anti‐Rous sarcoma response of major histocompatibility (B) complex haplotypes B 23 , B 24 and B 30
Author(s) -
TAYLOR R. L.,
CLARE R. A.,
WARD P. H.,
BRILES R. W.,
BRILES W. E.
Publication year - 1988
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1988.tb00816.x
Subject(s) - biology , rous sarcoma virus , group b , titer , haplotype , dominance (genetics) , b cell , virology , group a , microbiology and biotechnology , genotype , virus , genetics , antibody , gene , medicine
Summary. Responses to Rous sarcoma virus (RSV) induced tumours were studied in UNH 105, a non‐inbred line of New Hampshire chickens. Six single male matings encompassing a total of 50 dams produced 345 progeny which segregated for B complex genotypes B 23 /B 23 , B 23 /B 24 , B 23 /B 30 , B 24 /B 24 , B 24 /B 30 and B 30 /B 30 . Six‐week‐old chicks were wingweb inoculated with a pseudotype of Bryan high titre Rous sarcoma virus, BH RSV (RAV‐1). Tumours were scored for size six times over a 10‐week period post‐inoculation. Each chick was assigned a tumour profile index (TPI) as an indicator of immunological response. The number of days to death (DTD) was recorded for 148 chicks with terminal tumours. Genotypes B 23 /B 23 , B 23 /B 24 and B 23 /B 30 , with TPIs of 1.8, 1.7 and 2.0 respectively, did not differ significantly from each other, suggesting dominance of response of B 23 over B 24 and B 30 haplotypes. B 24 /B 30 chicks with the highest TPI (3.4) and shortest DTD (34.6) were significantly different from B 30 /B 30 (2.8; 41.6) but not from B 24 /B 24 (3.1; 34.9) suggesting dominance of response of the B 24 haplotype over B 30 in the absence of B 23 .