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Evidence for transferrin polymorphism in Spanish wild rabbits
Author(s) -
ARANA A.,
ZARAGOZA P.,
RODELLAR C.,
AMORENA B.
Publication year - 1987
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.1987.tb00751.x
Subject(s) - transferrin , sialic acid , biology , neuraminidase , locus (genetics) , allele , polymorphism (computer science) , population , genetics , phenotype , microbiology and biotechnology , polyacrylamide gel electrophoresis , biochemistry , gene , enzyme , virus , demography , sociology
Summary. Serum samples from 412 Spanish wild rabbits were analysed by starch and polyacrylamide gel electrophoresis. Three different transferrin (Tf) phenotypes (A, AB and B) were observed by both methods. The occurrence of two codominant alleles (Tf A and Tf B with frequencies of 0.89 and 0.11 respectively) at an autosomal locus (Tf) was supported by the population data on genetic equilibrium. Electrophoretic mobility differences between the Tf variants A and B could not be explained by differences in sialic acid or iron contents. Each of the two Tf variants were shown to have two sialic acid residues by neuraminidase treatment. These variants had similar affinities for iron, and iron binding did not lead to the conversion of one variant into the other.