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Blood group association with severity and speed of the halothane reaction 1
Author(s) -
Imlah P.
Publication year - 1984
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1984.tb01127.x
Subject(s) - genotype , allele , locus (genetics) , halothane , biology , genetics , offspring , linkage (software) , medicine , gene , anesthesia , pregnancy
Summary The second generation ( n = 227) of British Landrace pigs from selected halothane‐positive parents (36 litters) were blood‐typed for the S ( A‐0 ) , H and Phi loci and subjected to four 5‐minute halothane tests at 21, 35, 49 and 63 days of age. Cumulative scores based on seventy and speed of reaction were analysed in relation to single‐locus blood group genotypes and linkage group sequences at two and three loci. A highly significant negative correlation ( r = ‐0.79) was found between severity and speed of reaction. Significant differences occurred between blood group genotypes and linkage groups in both severity and speed of reaction. Genotypes S s/s, H a/a or H a/‐ and Phi B/B and linkage groups involving these three types had the highest cumulative reaction score and the fastest reaction time, whereas genotypes Phi A/B, S S/S or S S/s and H a/cd and linkage groups with these types had the Iowest and slowest reaction scores. Some differences between genotypes and linkage groups were attributed to phenotypically halothane‐positive parents and offspring being genotypically Hal N/n . These effects could result from linkage with heterozygous types such as H a/cd and S S/s. The possible role of the H cd allele acting as a genetic marker for a suppressor gene to the halothane reaction is discussed.