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The plasma protease inhibitor system (Pi) of Standardbred horses
Author(s) -
Bell K.,
Patterson S.,
Pollitt C. C.
Publication year - 1984
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1984.tb01116.x
Subject(s) - pi , allele , trypsin , neutral protease , microbiology and biotechnology , protease , biology , trypsin inhibitor , chymotrypsin , staining , polyacrylamide gel electrophoresis , protease inhibitor (pharmacology) , kunitz sti protease inhibitor , genetics , enzyme , biochemistry , gene , virus , antiretroviral therapy , viral load
Summary The plasma protease inhibitor system (Pi) of Standardbred horses was studied by thin‐layer, high‐voltage, acid polyacrylamide gel electrophoresis (pH 4.6) followed by protein staining and staining for trypsin and chymotrypsin inhibition. In addition to the eight Thoroughbred alleles ( Pi F, g, i, L, N, S1, S2, u) , another 10 alleles, designated PiH, j, k, o , p , q , r , v , x, z , were postulated to account for the 98 Pi types which were observed in Standardbreds. Detailed inhibitory spectra of the ‘new’ alleles were determined and further exceptions to the Pil, Pi2 classification of Juneja et al. (1979) were found. Limited family data demonstrated the genetic nature of the ‘new’ variants and confirmed the allelic inheritance of the ‘new’ Pi variants.