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Genetic polymorphism of the vitamin D binding protein (Gc) in the musk shrew (Suncus murinus)
Author(s) -
Iseki Rieko,
Kondo Kyoji
Publication year - 1984
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1984.tb01097.x
Subject(s) - vitamin d binding protein , suncus , biology , allele , microbiology and biotechnology , locus (genetics) , phenotype , shrew , albumin , vitamin , genetics , biochemistry , gene , endocrinology , ecology
Summary In the musk shrew ( Suncus murinus ), the electrophoretic bands in the post‐albumin region were identified as vitamin D binding protein (Gc) by the [ 3 HI vitamin D 3 binding method. Three Gc phenotypes were distinguished from each other: a single faster band (Gc‐A), a single slower band (Gc‐B) and the double bands (Gc‐AB). Results of mating experiments indicated that the Gc‐A and Gc‐B are controlled by two codominant alleles, Cc a and Gc b at an autosomal locus ( Cc ), respectively. It was noticed that, in the Gc‐AB phenotypes, the Gc‐B band was constantly more intense than the Gc‐A band in the protein staining. The same tendency was also observed btween the homozygous Gc‐A and Gc‐B bands, and further, radioactivity of the Gc‐B bound with [ 3 H] vitamin D 3 was about twofold higher than that of the Gc‐A. These results suggest that the Gc b yields its protein product twofold more than the Gc a . No cross‐reaction between the shrew proteins and a rabbit anti‐human Gc protein was observed.