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The pig histocompatibility system SLA: Serological study on a group of antigenic specificities
Author(s) -
Renard Christine,
Chardon P.,
Vaiman M.
Publication year - 1982
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1982.tb01578.x
Subject(s) - linkage disequilibrium , biology , genetics , haplotype , allele , population , major histocompatibility complex , linkage (software) , antigen , gene , demography , sociology
Summary The report presents an analysis of a group of class I SLA reagents which were highly correlated within one cluster in a previous analysis. Further population and family studies, and selected purification of several of these reagents led to the identification of 4 distinct specificities, namely SLA A 15, B 18, C 1 and A 16. Three of them, SLA A 15, B 18 and C 1, are actually in strong linkage disequilibrium and represent the main SLA haplotype in the Large White breed. SLA A 16 is present essentially in the Landrace breeds. SLA A 16 displays a strong cross‐reaction with SLA A 15 and there is another specificity in linkage disequilibrium with SLA A 16 which cross‐reacts with SLA B 18. Altogether, the strong linkage disequilibrium and the high degree of cross‐reactivity among the allelic products of the SLA complex explain the failure to detect the diversity of our reagents in previous studies.