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Sorbitol dehydrogenase genetics in the mouse: A ‘;null’ mutant in a ‘;European’ C57BL strain
Author(s) -
Holmes Roger S.,
Duley John A.,
Hilgers J.
Publication year - 1982
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1982.tb01569.x
Subject(s) - sorbitol dehydrogenase , biology , locus (genetics) , alcohol dehydrogenase , isozyme , sorbitol , genetics , mutant , microbiology and biotechnology , null allele , dehydrogenase , phenotype , enzyme , biochemistry , gene
Summary A ‘;null’ activity variant phenotype for sorbitol dehydrogenase (SDH) was observed in C57BL/LiA mice and used to examine the genetics of this enzyme. Linkage studies of the locus ( Sdh‐1 ) with non‐agouti (a) and a biochemical Iocus encoding liver L‐α‐hydroxyacid oxidase ( Hao‐1 ) demonstrated that it is coincident with or closely linked to the structural locus, previously localized on chromosome 2. Alcohol dehydrogenase (ADH) isozymes were also examined, since the liver A 2 isozyme exhibited some activity as a sorbitol dehydrogenase on cellulose acetate zymograms. It is apparent that SDH activity is not ‘;essential’ in this mouse strain.