Premium
The human Duffy blood group in rhesus monkeys 1
Author(s) -
Stong Robin C.,
Stone W. H.
Publication year - 1980
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1980.tb01506.x
Subject(s) - plasmodium knowlesi , biology , antigen , abo blood group system , rh blood group system , serology , virology , plasmodium vivax , human blood , malaria , immunology , antibody , plasmodium falciparum , physiology
Summary There is good evidence that susceptibility to Plasmodium vivax infection and to P. knowlesi erythrocyte invasion is influenced by certain human Duffy (Fy) blood group antigens. Since P. knowlesi readily infects rhesus monkeys (Macaca mulatto), it was not surprising to find an Fy‐like antigen on rhesus erythrocytes. Using human Fy antisera in elution and absorption experiments, we found that all 40 rhesus monkeys tested displayed the Fy(a‐b +) phenotype. Furthermore, the rhesus Fy b antigen was inactivated by chymotrypsin but not by trypsin, suggesting that it is homologous to the human Fy b antigen. Preliminary serological analyses and enzyme hydrolysis experiments suggest that none of the 13 blood group systems that we have described in rhesus are analogous to the human Fy system. Thus, it appears that there is no Duffy‐like polymorphism in rhesus monkeys.