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Close linkage between the C blood group locus and the locus controlling amino acid transport in sheep erythrocytes
Author(s) -
Tucker E. M.,
Evans N. R. S.,
Kilgour L.
Publication year - 1980
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1980.tb01502.x
Subject(s) - biology , amino acid , locus (genetics) , genetics , phenotype , glutathione , hemoglobin c , microbiology and biotechnology , red blood cell , biochemistry , enzyme , gene , hemoglobin
Summary Data from 838 Finnish Landrace or Finnish Landrace crossbred sheep showed a highly significant correlation between phenotypes of the C blood group system and erythrocyte amino acid transport variants. Erythrocytes with normal amino acid transport properties (GSH high, Ly‐ type) were Cb‐positive or Cb‐negative. Erythrocytes with the amino acid transport lesion (GSH low, Ly +) were never Cb‐negative. Sheep erythrocytes homozygous for C b showed stronger lysis reactions with anti‐Cb than heterozygous cells. Ly + sheep were nearly always homozygous for C b , whereas most Ly‐ sheep were heterozygous or Cb‐negative. Inheritance studies provided strong evidence that this association is due to close genetic linkage.