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Genetic control of the immune response in lines of chickens selected for graft‐versus‐host competences
Author(s) -
Okabayashi Hisato,
Okada Ikuo
Publication year - 1977
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1977.tb01627.x
Subject(s) - immune system , biology , antiserum , antibody , major histocompatibility complex , genotype , locus (genetics) , immunology , histocompatibility , antigen , genetics , gene , human leukocyte antigen
Summary The immune response of chickens to goat erythrocytes has been examined. The H line selected for high competence of graft‐versus‐host reaction (GVHR) showed higher immune responses than the L line selected for low GVHR competence. It appeared also that immune responses were controlled by the B blood group locus, which is the major histocompatibility locus in chickens. The relative immune responsiveness of B genotypes were B 11 / 11 > B 9 / B 11 > B 9 /B 9 . Treatment of antiserum with 2‐mercaptoethanol (2‐ME) proved that the difference in immune responses between lines was due mainly to the 2‐ME resistant antibody and that the difference between the B genotypes was due to the 2‐ME sensitive antibody.