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Genetic polymorphism of leucine aminopeptidase in canine plasma
Author(s) -
Tanabe Yuichi,
Sugiura Shuji,
Asanoma Masaharu,
Ota Katuaki
Publication year - 1974
Publication title -
animal blood groups and biochemical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0003-3480
DOI - 10.1111/j.1365-2052.1974.tb01337.x
Subject(s) - aminopeptidase , isozyme , leucyl aminopeptidase , biology , locus (genetics) , allele , leucine , genetics , polymorphism (computer science) , gene , breed , phenotype , microbiology and biotechnology , enzyme , biochemistry , amino acid
Summary Genetic polymorphism was found in the isozymes of leucine aminopeptidase in the canine plasma. Analysis of parentage records of the dogs examined revealed that the phenotypic variation of leucine aminopeptidase isozymes was controlled by one autosomal locus, designated Lap , with two codominant gene alleles, Lap A and Lap B , though individuals of homozygous B type were not found in the specimen used. The gene frequencies were 0.97 for Lap A and 0.03 for Lap B in most of the dog breeds examined. Higher frequencies for Lap B (0.11–0.25) were obtained in breeds such as Pointer, Doberman pinscher, Boxer, Borzoi and San'in‐Shiba (a Japanese native breed), while in German shepherd, Collie, and two of the Japanese native breeds, Akita and Kishu, phenotype of the isozyme seemed to be fixed to homozygous A ( Lap A / Lap A ).