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A randomised controlled trial of dexmedetomidine for suspension laryngoscopy
Author(s) -
Liu C.,
Zhang Y.,
She S.,
Xu L.,
Ruan X.
Publication year - 2013
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07331.x
Subject(s) - dexmedetomidine , medicine , anesthesia , propofol , intubation , medetomidine , placebo , bradycardia , laryngoscopy , loading dose , heart rate , sedation , blood pressure , alternative medicine , pathology
Summary We randomly allocated 80 patients to intravenous dexmedetomidine (0.25, 0.5, or 1 μg.kg −1 ) or placebo 15 min before anaesthetic induction. Dexmedetomidine 0.5 and 1.0 μg.kg −1 significantly reduced the mean (95% CI) propofol effect‐site concentrations by 0.83 (0.63–1.03) μg.ml −1 , p = 0.001 and 1.29 (1.12–1.46) μg.ml −1 , p = 0.0003 at intubation, by 1.05 (0.85–1.25 μg.ml −1 , p = 0.0006 and 1.33 (1.15–1.51) μg.ml −1 , p = 0.0002 when surgery started, and by 0.59 (0.39–0.79) μg.ml −1 , p = 0.030 and 0.72 (0.57–0.87) μg.ml −1 , p = 0.004 on completion of surgery, respectively. Patients’ tracheas were extubated sooner after 0.5 and 1.0 μg.kg −1 dexmedetomidine, by 5.36 (2.39–8.32) min, p = 0.009 and 7.37 (3.24–11.51) min p = 0.003, respectively. Tachycardic responses to intubation were present in five placebo patients and no dexmedetomidine patients. Bradycardia was treated after dexmedetomidine in six patients: five after 1.0 μg.kg −1 ; and one after 0.25 μg.kg −1 . Single‐dose dexmedetomidine can reduce anaesthetic requirements, with both desirable and undesirable haemodynamic effects.