Premium
A randomised comparison of two intranasal dexmedetomidine doses for premedication in children
Author(s) -
Yuen V. M.,
Hui T. W.,
Irwin M. G.,
Yao T. J.,
Chan L,
Wong G. L.,
Shahnaz Hasan M.,
Shariffuddin I. I.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07309.x
Subject(s) - dexmedetomidine , medicine , premedication , sedation , anesthesia , nasal administration , odds ratio , logistic regression , randomized controlled trial , adverse effect , prospective cohort study , surgery , immunology
Summary We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 μg.kg −1 (Group 1) or 2 μg.kg −1 (Group 2). Thirty‐one (53%) patients from Group 1 and 38 (66%) patients from Group 2 were satisfactorily sedated at the time of anaesthetic induction. Logistic regression showed a significant interaction effect (p = 0.049), with the odds ratio between Group 2 over Group 1 estimated as 1.1 (95% CI 0.5–2.7) for the 1–4 year age group, and 10.5 (95% CI 1.4–80.2) for the 5–8 year age group. Both doses produced a similar level of satisfactory sedation in children aged 1–4 years, whereas 2 μg.kg −1 resulted in a higher proportion of satisfactory sedation in children aged 5–8 years. There were no adverse haemodynamic effects. We conclude that intranasal dexmedetomidine in a premedication dose of 2 μg.kg −1 resulted in excellent sedation in children.