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Modulation of pain sensation by stress‐related testosterone and cortisol
Author(s) -
Choi J. C.,
Chung M. I.,
Lee Y. D.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07267.x
Subject(s) - testosterone (patch) , medicine , anxiety , sensation , stimulation , hydrocortisone , endocrinology , psychology , psychiatry , neuroscience
Summary Stress increases cortisol and decreases testosterone. It is not known whether pain is affected by stress‐related testosterone. Therefore, we investigated whether stress can affect pain perception by decreasing testosterone and increasing cortisol. Pain thresholds, pain and anxiety ratings and salivary testosterone and cortisol levels were measured in 46 healthy men during resting and stressful conditions. Pain was induced by electrical stimulation. Stress was induced by having participants perform a medical test. Stress significantly increased anxiety ratings and salivary cortisol levels, but decreased salivary testosterone levels. Stress also increased pain ratings and decreased pain thresholds. During stress, cortisol levels were negatively correlated with pain thresholds and testosterone levels were positively correlated with pain thresholds. Results indicated that testosterone can decrease and cortisol can increase pain induced by electrical stimulation, suggesting that acute clinical pain may be relieved by controlling stress and managing consequent stress‐related testosterone and cortisol.