Premium
Effect of hyperoxia and vascular occlusion on tissue oxygenation measured by near infra‐red spectroscopy (InSpectra™): a volunteer study
Author(s) -
Kyle B.,
Litton E.,
Ho K. M.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07265.x
Subject(s) - hyperoxia , medicine , oxygen , oxygenation , ischemia , anesthesia , oxygen saturation , cardiology , hemoglobin , perfusion , peripheral , lung , chemistry , organic chemistry
Summary Standard cardiorespiratory monitoring may fail to detect occult tissue ischaemia. This study assessed whether a near infra‐red spectroscopy tissue oxygen saturation monitor (InSpectra™) could detect progressive peripheral tissue ischaemia and whether hyperoxia may confound tissue oxygen saturation measurement. Tissue oxygen and arterial oxygen saturations were measured continuously in 30 healthy volunteers, first during a period of progressive increase in inspired oxygen concentration and subsequently during two periods of low‐ and high‐pressure limb ischaemia. Increasing inspired oxygen concentration was associated with a small increase in mean (SD) tissue oxygen saturation of 5.3 (7.1) %, reaching a plateau between 30% and 40% inspired oxygen. The rate and magnitude of decreases in tissue oxygen saturations were greater during high‐ than low‐pressure ischaemia with a mean (SD) desaturation rate of 3.3 (0.9) vs 1.8 (0.8) %.min −1 (p < 0.01). The dose‐related association and lack of confounding by hyperoxia suggest that tissue oxygen saturation monitoring may be a useful adjunct to detect occult ischaemia.