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Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM ® ) *
Author(s) -
Na H. S.,
Chung Y. H.,
Hwang J. W.,
Do S. H.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2012.07149.x
Subject(s) - thromboelastometry , magnesium , medicine , anesthesia , clotting time , saline , coagulation , surgery , chemistry , organic chemistry
Summary We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg −1 followed by continuous infusion of 15 mg.kg −1 .h −1 ), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l −1 in the magnesium group compared with 0.98 (0.06) mmol.l −1 in the control group (p < 0.001). Postoperative clotting time, clot formation time, α‐angle and maximum clot firmness of INTEM, and clot formation time, α‐angle, and maximum clot firmness of EXTEM were significantly different between the two groups (p < 0.05). Intra‐operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.