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The effect of temperature on di(2‐ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions
Author(s) -
Rose R. J.,
Priston M. J.,
RigbyJones A. E.,
Sneyd J. R.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2011.07006.x
Subject(s) - phthalate , plasticizer , medicine , saline , leaching (pedology) , vinyl chloride , preservative , anesthesia , chromatography , chemistry , food science , biology , polymer , organic chemistry , copolymer , soil water , ecology
Summary Poly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2‐ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA ® Infusion sets, into lipid and non‐lipid infusates. Two propofol admixtures (Diprivan ® 1%, Propoven ® 1%), Intralipid ® 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h −1 for 6 h at 24, 32 and 37 °C. In addition, TIVA sets were filled with 2 ml infusates, sealed and incubated at 24 and 37 °C for 6 h. Di(2‐ethylhexyl) phthalate was detected in all lipid infusates after dynamic infusion and static contact, and in 0.9% saline after dynamic infusion at 37 °C. At 32 and 37 °C, the quantity of di(2‐ethylhexyl) phthalate leaching into the lipid infusates may exceed the recommended maximum exposure amount set by the European Union for DEHP of 20–48 μg.kg −1 .day −1 if lipid based infusates are used for sedation or intravenous feeding of infants or neonates.