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Limited maximal flow rate of target‐controlled remifentanil infusion and induced cough
Author(s) -
Min S. K.,
Kim D. H.,
Cho H. B.,
Moon B. K.,
Kim J. Y.
Publication year - 2012
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2011.06961.x
Subject(s) - medicine , remifentanil , anesthesia , limiting , incidence (geometry) , mechanical engineering , physics , optics , engineering , propofol
Summary This study evaluated the effect of limiting maximal infusion‐pump flow rate on suppression of remifentanil‐induced cough during target‐controlled infusion. Two hundred and ten patients were randomly assigned to receive remifentanil at an effect‐site concentration of 4.0 ng.ml −1 with maximal flow rate limited to 100 (group R 100 ), 200 (group R 200 ), or 1200 ml.h −1 (group R 1200 ). The number of episodes of cough were recorded and graded as mild (1–2), moderate (3–4), or severe (5 or more). The incidence of cough was 2.9% in group R 100 , 5.7% in group R 200 and 25.7% in group R 1200 . Patients in group R 100 and R 200 had a significantly lower incidence of cough than those in group R 1200 (p < 0.05). Zero, two and five patients coughed a moderate amount in groups R 100 , R 200 and group R 1200 , respectively (p < 0.05). Limiting maximal infusion rate during remifentanil TCI suppressed remifentanil‐induced cough.