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Association of human μ‐opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients
Author(s) -
Zhang W.,
Chang Y. Z.,
Kan Q. C.,
Zhang L. R.,
Lu H.,
Chu Q. J.,
Wang Z. Y.,
Li Z. S.,
Zhang J.
Publication year - 2010
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2009.06193.x
Subject(s) - fentanyl , medicine , opioid receptor , opioid , anesthesia , allele , pain tolerance , genotype , threshold of pain , gastroenterology , receptor , gene , genetics , biology
Summary One hundred and seventy‐four Chinese gynaecology patients were studied for the impact of A118G polymorphism in the μ‐opioid receptor gene ( OPRM1 ) on pain sensitivity and postoperative fentanyl consumption. Pre‐operatively, the pain threshold and pain tolerance threshold were measured using electrical stimulation. A118G polymorphism was genotyped using the polymerase chain reaction–restriction fragment length polymorphism method. Intravenous fentanyl patient‐controlled analgesia provided postoperative pain management, assessed using a visual analogue scale and fentanyl consumed in the first 24 h after surgery was noted. We found the prevalence of G118 allele was 31.3%. The A118G polymorphism had a gene‐dose‐dependent effect on electrical pain tolerance threshold. Fentanyl consumption was also significantly different in patients with different OPRM1 genotypes (homozygotes for 118G consumed more than did heterozygotes or homozygotes for 118A). Fentanyl consumption increased in accordance with the number of 118G alleles. We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control.