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The effect of pre‐emptive use of minimal dose fentanyl on fentanyl‐induced coughing
Author(s) -
Hung K.C.,
Chen C.W.,
Lin V. C.H.,
Weng H.C.,
Hsieh S.W.
Publication year - 2010
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2009.06109.x
Subject(s) - fentanyl , medicine , anesthesia , saline , bolus (digestion) , intravenous bolus , surgery
Summary We performed a randomised, double‐blind study to evaluate the effect of the pre‐emptive use of minimal dose intravenous fentanyl (25 μg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Six hundred patients were randomly assigned to one of three groups to receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 μg (3 ml), or pre‐emptive fentanyl 25 μg (0.5 ml) 1 min before administration of fentanyl 125 μg or 150 μg. The incidence of fentanyl‐induced cough was significantly lower in both pre‐emptive groups (7 (3.5%) for 125 μg fentanyl and 15 (7.5%) for 150 μg fentanyl) than in the saline group (37 (18.5%); p = 0.001). We conclude that pre‐emptive use of fentanyl 25 μg, administered 1 min before bolus injection of fentanyl (125 or 150 μg), can effectively suppress fentanyl‐induced cough.