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Optimal remifentanil dosage for providing excellent intubating conditions when co‐administered with a single standard dose of propofol
Author(s) -
Bouvet L.,
Stoian A.,
Rimmelé T.,
Allaouchiche B.,
Chassard D.,
Boselli E.
Publication year - 2009
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2009.05916.x
Subject(s) - remifentanil , medicine , propofol , anesthesia , intubation , tracheal intubation
Summary This dose–response study aimed to determine the dose of remifentanil combined with propofol 2.5 mg.kg −1 which provided excellent intubation conditions in 95% of patients. Ninety premedicated female ASA 1 and 2 patients were randomly allocated to five remifentanil dose groups (1, 2, 3, 4 or 5 μg.kg −1 ). Induction of anaesthesia was performed with a blinded dose of remifentanil infused over 60 s simultaneously co‐administered with propofol 2.5 mg.kg −1 infused over 45 s. Tracheal intubation was attempted 150 s after the beginning of induction. Intubating conditions were assessed with the Copenhagen score. A probit analysis was performed to calculate the intubating efficient doses (IED) of remifentanil in 95% of patients (IED 95 ). Our data revealed that the IED 95 of remifentanil was 4.0 (95% CI: 3.4–5.6) μg.kg −1 , which was associated with a maximum decrease in heart rate and mean arterial pressure of < 30%, a finding which also applied to the other groups.