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Influence of promethazine on cardiac repolarisation: a double‐blind, midazolam‐controlled study
Author(s) -
Owczuk R.,
Twardowski P.,
DylczykSommer A.,
Wujtewicz M. A.,
Sawicka W.,
Drogoszewska B.,
Wujtewicz M.
Publication year - 2009
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2009.05890.x
Subject(s) - medicine , promethazine , qt interval , anesthesia , midazolam , cardiology , prolongation , heart rate , electrocardiography , blood pressure , sedation
Summary Drugs used in anaesthesia may provoke torsadogenic changes in cardiac repolarisation. The aim of this study was to assess the effect of promethazine on the parameters of ventricular repolarisation: QTc interval and transmural dispersion of repolarisation. Forty patients were randomly allocated to receive promethazine (25 mg) or midazolam (2.5 mg). Changes in the ECG and arterial blood pressure were recorded. Correction of QT interval was calculated using Bazett’s formula and Fridericia’s correction; transmural dispersion of repolarisation was determined as T peak – T end time. Significant prolongation of QT interval, corrected with both formulae, was detected in patients receiving promethazine, while no change in the QTc value was observed in the midazolam group. There were no significant differences in T peak – T end time either between or within the groups. In conclusion, promethazine induces significant QTc prolongation but the lack of influence on transmural dispersion of repolarisation makes the risk of its torsadogenic action very low.