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Effect‐site concentration of remifentanil for laryngeal mask airway insertion during target‐controlled infusion of propofol
Author(s) -
Kim M. K.,
Lee J. W.,
Jang D. J.,
Shin O. Y.,
Nam S. B.
Publication year - 2009
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2008.05707.x
Subject(s) - remifentanil , propofol , medicine , anesthesia , laryngeal mask airway , target controlled infusion , airway , laryngeal masks , neuromuscular blockade , blockade , receptor
Summary The purpose of this study was to determine the effect‐site concentration of remifentanil that would provide optimal conditions for successful laryngeal mask airway insertion during a target‐controlled infusion (TCI) of propofol at 3.5 μg.ml −1 without the use of neuromuscular blockade. Five minutes after propofol infusion, remifentanil was infused at a dose determined by a modified Dixon’s up‐and‐down method. Five minutes after remifentanil infusion, the laryngeal mask was inserted. The effect‐site concentration of remifentanil for successful laryngeal mask insertion in 50% of adults (EC 50 ) was 3.04 (SD 0.49) ng.ml −1 during a TCI of 3.5 μg.ml −1 propofol without neuromuscular blockade. From the probit analysis, the EC 50 and EC 95 of remifentanil were 2.84 ng.ml −1 (95% CI 2.09–3.57 ng.ml −1 ) and 3.79 ng.ml −1 (95% CI 3.26–9.25 ng.ml −1 ), respectively.