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The effect of bolus administration of remifentanil on QTc interval during induction of sevoflurane anaesthesia
Author(s) -
Kweon T. D.,
Nam S. B.,
Chang C. H.,
Kim M. S.,
Lee J. S.,
Shin C. S.,
June D. B.,
Han D. W.
Publication year - 2008
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2007.05372.x
Subject(s) - remifentanil , medicine , anesthesia , tracheal intubation , intubation , laryngoscopy , sevoflurane , qt interval , bolus (digestion) , propofol , surgery
Summary Stimulation of the sympathetic nervous system associated with tracheal intubation causes corrected QT (QTc) interval prolongation. We postulated that the use of remifentanil during induction of anaesthesia might prevent this. Sixty unpremedicated, ASA grade 1 patients were selected and randomly allocated to receive either saline (group S), remifentanil 0.5 μg.kg −1 (group R 0.5) or remifentanil 1.0 μg.kg −1 (group R1.0) 1 min before laryngoscopy. The QTc interval was significantly prolonged immediately following intubation in group S and group R0.5, but it remained stable in group R1.0, compared with the QTc interval just before laryngoscopy. It is concluded that the administration of remifentanil 1.0 μg.kg −1 before intubation can prevent the prolongation of the QTc interval associated with tracheal intubation during induction of anaesthesia with sevoflurane.