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Pulmonary function and inflammatory markers in patients undergoing coronary revascularisation with or without cardiopulmonary bypass
Author(s) -
Heijmans J. H.,
Liem K. S. A. E.,
Damoiseaux G. M. C.,
Maessen J. G.,
Roekaerts P. M. H. J.
Publication year - 2007
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2007.05254.x
Subject(s) - medicine , cardiopulmonary bypass , lung , cardiology , oxygenation , pulmonary function testing , cardiac surgery , coronary artery bypass surgery , artery , tumor necrosis factor alpha , anesthesia
Summary Lung injury after cardiac surgery is believed to result from cardiopulmonary bypass and its pro‐inflammatory effects. To test this hypothesis, we compared the oxygenation ratios, extravascular lung water indices and systemic and pulmonary tumour necrosis factor alpha (TNF‐α) and interleukin (IL)‐8 at predetermined intervals in coronary artery surgery patients with or without cardiopulmonary bypass. No differences in oxygenation ratios or extravascular lung water indices were found. Serum values of TNF‐α and IL‐8 increased in both groups but were higher in the cardiopulmonary bypass group (end of surgery: mean (SD) TNF‐α 3.68 (2.5) vs 2.20 (1.2) pg.ml −1 (p = 0.043 (CI 0.05–2.9)) and mean (SD) IL‐8 19.45 (10.8) vs 6.31 (5.3) pg.ml −1 (p = 0.001 (CI 6.9–19.3)). In broncho‐alveolar lavage fluid, TNF‐α and IL‐8 increased in both groups with no differences between the groups.