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The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting *
Author(s) -
Rüsch D.,
Arndt C.,
Martin H.,
Kranke P.
Publication year - 2007
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2007.05136.x
Subject(s) - dexamethasone , medicine , haloperidol , nausea , postoperative nausea and vomiting , placebo , anesthesia , vomiting , antiemetic , corticosteroid , surgery , dopamine , alternative medicine , pathology
Summary It is not known whether dexamethasone increases the effectiveness of anti‐emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone, or haloperidol and dexamethasone. The results from 228 patients were suitable for analysis. PONV recurred significantly less frequently in patients treated with additional dexamethasone (33%) than in patients treated without additional dexamethasone (51%). The combination of dexamethasone with dolasetron or dexamethasone with haloperidol is superior to dolasetron or haloperidol alone for the treatment of PONV.