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The effect of cigarette smoking on the hypnotic efficacy of propofol
Author(s) -
Lysakowski C.,
Dumont L.,
Czarnetzki C.,
Bertrand D.,
Tassonyi E.,
Tramèr M. R.
Publication year - 2006
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2006.04747.x
Subject(s) - propofol , medicine , hypnotic , bispectral index , anesthesia , sedation
Summary The bispectral index (BIS) was used to examine the hypnotic efficacy of propofol in 25 smokers (20 cigarettes/day for 2 years) and 24 matched non‐smokers (same gender, age, height, weight). BIS was recorded at baseline, at four incremental effect‐site concentrations of propofol and at loss of consciousness. Compared with non‐smokers, smokers were found to have higher BIS values at baseline (mean (SD)) (97 (1) vs 98 (1)), at 0.7 μg.ml −1 (95 (3) vs 97 (1)) and at 1.1 μg.ml −1 (89 (6) vs 94 (4)), p = 0.0099, and they lost consciousness at higher propofol concentrations (2.0 (0.4) vs 2.4 (0.8) μg.ml −1 ), p = 0.03, and at lower BIS values (66 (10) vs 60 (10)), p = 0.04. The hypnotic efficacy of propofol is reduced when used at low effect‐site concentrations in smokers. This phenomenon may have some impact on the management of smokers undergoing sedation using target controlled infusion systems.