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Idiopathic non‐histaminergic angio‐oedema after routine extubation successfully treated with fresh frozen plasma
Author(s) -
Franzen D.,
Ursprung T.,
Wuthrich B.,
Reber A.
Publication year - 2006
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2006.04648.x
Subject(s) - medicine , fresh frozen plasma , angioedema , anesthesia , histaminergic , laryngeal edema , anaphylaxis , edema , surgery , histamine , dermatology , allergy , immunology , platelet
Summary Non‐allergic angio‐oedema is a potentially life‐threatening condition typically seen in patients with hereditary or acquired angio‐oedema caused by C1 inhibitor deficiency or an adverse drug reaction to angiotensin converting enzyme inhibitors. We report a case of sudden angio‐oedema in a patient who developed severe swelling of the tongue and neck after routine extubation requiring resuscitative re‐intubation. The oedema was refractory to conventional allergy treatment. Shortly thereafter, the patient was treated with fresh frozen plasma, and within a few hours his condition improved, allowing extubation. Familial history and exposure to potentially angio‐oedema causative drugs were not evident. The serum complement status was normal, and no IgE sensitisation was detected. We therefore concluded that the patient was suffering from idiopathic non‐histaminergic angio‐oedema. To our knowledge, this is the first reported case of an acute, life‐threatening attack of idiopathic non‐histaminergic angio‐oedema that was successfully treated with fresh frozen plasma.