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Statin therapy: a potentially useful peri‐operative intervention in patients with cardiovascular disease
Author(s) -
Biccard B. M.,
Sear J. W.,
Foëx P.
Publication year - 2005
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2005.04405.x
Subject(s) - medicine , disease , perioperative , statin , peri , intervention (counseling) , intensive care medicine , atherosclerotic cardiovascular disease , physical therapy , surgery , psychiatry
Summary Statin cardiovascular protection is mediated by lipid lowering and pleiotropic effects. The efficacy of statins has been established in non‐surgical patients with cardiovascular disease and also more recently in non‐surgical patients who sustain an acute coronary event. Peri‐operative statin administration has been shown to improve both short‐term and long‐term cardiac outcome following non‐cardiac and coronary bypass graft surgery. This cardioprotection may be independent of peri‐operative haemodynamics due to a positive effect on plaque stability. Recommendations for the peri‐operative statin administration are suggested. These include indications for peri‐operative statin therapy, timing of administration, therapeutic targets, duration of administration, the adverse implications of peri‐operative statin withdrawal, safety and cost‐effectiveness.