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Effects of short‐term propofol administration on pancreatic enzymes and triglyceride levels in children
Author(s) -
Gottschling S.,
Meyer S.,
Krenn T.,
Kleinschmidt S.,
Reinhard H.,
Graf N.,
Shamdeen G. M.
Publication year - 2005
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2005.04231.x
Subject(s) - medicine , propofol , triglyceride , sedation , pancreatitis , endocrinology , anesthesia , gastroenterology , cholesterol
Summary This prospective, clinical trial evaluated the effects of short‐term propofol administration on triglyceride levels and serum pancreatic enzymes in children undergoing sedation for magnetic resonance imaging. Laboratory parameters of 40 children, mean age (SD; range) 67 (66; 4–178) months undergoing short‐term sedation were assessed before and 4 h after having received propofol. Mean (SD) propofol loading dose was 2.2 (1.1) mg.kg −1 followed by continuous propofol infusion of 6.9 (0.9) mg.kg −1 .h −1 . Serum lipase levels (p = 0.035) and serum triglyceride levels (p = 0.003) were raised significantly after propofol administration but remained within normal limits. No significant changes in serum pancreatic‐amylase levels were seen (p = 0.127). In two (5%) children, pancreatic enzymes and in four (10%) children triglyceride levels were raised above normal limits; however, no child showed clinical symptoms of pancreatitis. We conclude that even short‐term propofol administration with standard doses of propofol may have a significant effect on serum triglyceride and pancreatic enzyme levels in children.