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Effective doses of vecuronium in a patient with myotonic dystrophy *
Author(s) -
Nishi M.,
Itoh H.,
Tsubokawa T.,
Taniguchi T.,
Yamamoto K.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2004.03926.x
Subject(s) - myotonic dystrophy , medicine , orbicularis oculi muscle , adductor pollicis muscle , anesthesia , myotonia , ed50 , muscular dystrophy , neuromuscular transmission , surgery , eyelid , elbow , receptor , ulnar nerve
Summary Of the forms of muscular dystrophy, myotonic dystrophy has the greatest systemic involvement. Although most patients with myotonic dystrophy show normal sensitivity to non‐depolarising neuromuscular blocking drugs, some have been reported to show greatly increased sensitivity to these drugs, and little is known about the sensitivity of different muscles. We compared effective doses of vecuronium in a patient with myotonic dystrophy at the orbicularis oculi, adductor pollicis and flexor hallucis brevis muscles during total intravenous anaesthesia. The calculated ED 50 for the orbicularis oculi (7.77 μg.kg −1 (95% CI 3.10–16.8 μg.kg −1 )) was lower than for the adductor pollicis (25.3 μg.kg −1 (95% CI 20.7–43.3 μg.kg −1 )) and flexor hallucis brevis muscles (29.5 μg.kg −1 (95% CI 11.0–85.6 μg.kg −1 ; p < 0.01)). The ED 90 was also lower for the orbicularis oculi (35.7 μg.kg −1 (95% CI 14.8–66.5 μg.kg −1 )) than for the other muscles (51.8 μg.kg −1 (95% CI 29.3–145.0 μg.kg −1 ) and 50.6 μg.kg −1 (95% CI 5.29–642.0 μg.kg −1 ), respectively) (p < 0.01)).