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A prospective, randomised, single‐blind pilot study to determine the effect of anaesthetic technique on troponin T release after off‐pump coronary artery surgery
Author(s) -
Kendall J. B.,
Russell G. N.,
Scawn N. D. A.,
Akrofi M.,
Cowan C. M.,
Fox M. A.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2004.03713.x
Subject(s) - medicine , isoflurane , troponin , propofol , anesthesia , coronary artery bypass surgery , troponin t , unstable angina , artery , prospective cohort study , troponin i , myocardial infarction , cardiology , surgery
Summary Ischaemic damage to the myocardium inevitably occurs during coronary artery surgery. However, the extent of the damage may be influenced by the anaesthetic technique used. The most sensitive and reliable marker of myocardial damage is currently thought to be troponin T. We conducted a prospective, randomised, single‐blind pilot study to determine the baseline values of troponin T release after off‐pump coronary artery bypass surgery in 30 patients randomly allocated to receive either propofol, isoflurane or isoflurane and high thoracic epidural analgesia. All other treatment was standardised. Patients undergoing emergency surgery and those with unstable angina were excluded. Blood samples were taken at 0, 3, 6, 12, 24 and 48 h after surgery for troponin T analysis. Mean troponin T levels at 24 h were not significantly different between the groups ( p = 0.41). These data allows appropriate power calculations for further, large‐scale studies to determine the anaesthetic technique that provides optimal myocardial protection.